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Thiol-reducing agents prevent sulforaphane-induced growth inhibition in ovarian cancer cells

Title
Thiol-reducing agents prevent sulforaphane-induced growth inhibition in ovarian cancer cells
Authors
Kim, Seung CheolChoi, BoyunKwon, Youngjoo
Ewha Authors
권영주
SCOPUS Author ID
권영주scopus
Issue Date
2017
Journal Title
FOOD & NUTRITION RESEARCH
ISSN
1654-6628JCR Link1654-661XJCR Link
Citation
vol. 61
Keywords
Sulforaphanereactive oxygen scavengersthiol-reducing agentsdiamideovarian cancer
Publisher
TAYLOR &; FRANCIS LTD
Indexed
SCIE; SCOPUS WOS
Abstract
The inhibitory potential of sulforaphane against cancer has been suggested for different types of cancer, including ovarian cancer. We examined whether this effect is mediated by mitogen-activated protein kinase (MAPK) and reactive oxygen species (ROS), important signaling molecules related to cell survival and proliferation, in ovarian cancer cells. Sulforaphane at a concentration of 10 mu M effectively inhibited the growth of cancer cells. Use of specific inhibitors revealed that activation of MAPK pathways by sulforaphane is unlikely to mediate sulforaphane-induced growth inhibition. Sulforaphane did not generate significant levels of intracellular ROS. Pretreatment with thiol reducers, but not ROS scavengers, prevented sulforaphane-induced growth inhibition. Furthermore, diamide, a thiol-oxidizing agent, enhanced both growth inhibition and cell death induced by sulforaphane, suggesting that the effect of sulforaphane on cell growth may be related to oxidation of protein thiols or change in cellular redox status. Our data indicate that supplementation with thiol-reducing agents should be avoided when sulforaphane is used to treat cancer.
DOI
10.1080/16546628.2017.1368321
Appears in Collections:
엘텍공과대학 > 식품공학전공 > Journal papers
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