Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이승진 | - |
dc.date.accessioned | 2017-10-27T11:44:58Z | - |
dc.date.available | 2017-10-27T11:44:58Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1616-5187 | - |
dc.identifier.other | OAK-21260 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/237073 | - |
dc.description.abstract | Cell sheet transplantation is a key tissue engineering technology. A vascular endothelial growth factor (VEGF)-releasing fiber mat is developed for the transplantation of multilayered cardiomyocyte sheets. Poly(vinyl alcohol) fiber mats bearing poly(lactic-co-glycolic acid) nanoparticles that incorporate VEGF are fabricated using electrospinning and electrospray methods. Six-layered cardiomyocyte sheets are transplanted with a VEGF-releasing mat into athymic rats. After two weeks, these sheets produce thicker cardiomyocyte layers compared with controls lacking a VEGF-releasing mat, and incorporate larger-diameter blood vessels containing erythrocytes. Thus, local VEGF release near the transplanted cardiomyocytes induces vascularization, which supplies sufficient oxygen and nutrients to prevent necrosis. In contrast, cardiomyocyte sheets without a VEGF-releasing mat do not survive in vivo, probably undergo necrosis, and are reduced in thickness. Hence, these VEGF-releasing mats enable the transplantation of multilayered cardiomyocyte sheets in a single procedure, and should expand the potential of cell sheet transplantation for therapeutic applications. (Figure presented.). © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | - |
dc.language | English | - |
dc.publisher | Wiley-VCH Verlag | - |
dc.subject | cell sheet | - |
dc.subject | electrospun fiber | - |
dc.subject | regenerative medicine | - |
dc.subject | tissue engineering | - |
dc.subject | VEGF | - |
dc.title | Local Release of VEGF Using Fiber Mats Enables Effective Transplantation of Layered Cardiomyocyte Sheets | - |
dc.type | Article | - |
dc.relation.issue | 8 | - |
dc.relation.volume | 17 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.journaltitle | Macromolecular Bioscience | - |
dc.identifier.doi | 10.1002/mabi.201700073 | - |
dc.identifier.wosid | WOS:000409001400012 | - |
dc.identifier.scopusid | 2-s2.0-85019891746 | - |
dc.author.google | Nagase K. | - |
dc.author.google | Nagumo Y. | - |
dc.author.google | Kim M. | - |
dc.author.google | Kim H.-J. | - |
dc.author.google | Kyung H.-W. | - |
dc.author.google | Chung H.-J. | - |
dc.author.google | Sekine H. | - |
dc.author.google | Shimizu T. | - |
dc.author.google | Kanazawa H. | - |
dc.author.google | Okano T. | - |
dc.author.google | Lee S.-J. | - |
dc.author.google | Yamato M. | - |
dc.contributor.scopusid | 이승진(57196249292) | - |
dc.date.modifydate | 20230201093329 | - |