Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 임경민 | * |
dc.date.accessioned | 2017-10-27T11:44:57Z | - |
dc.date.available | 2017-10-27T11:44:57Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 1976-9148 | * |
dc.identifier.other | OAK-21266 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/237068 | - |
dc.description.abstract | Increasing concern is being given to the association between risk of cancer and exposure to low-dose bisphenol A (BPA), especially in young-aged population. In this study, we investigated the effects of repeated oral treatment of low to high dose BPA in juvenile Sprague-Dawley rats. Exposing juvenile rats to BPA (0, 0.5, 5, 50, and 250 mg/kg oral gavage) from post-natal day 9 for 90 days resulted in higher food intakes and increased body weights in biphasic dose-effect relationship. Male mammary glands were atrophied at high dose, which coincided with sexual pre-maturation of females. Notably, proliferative changes with altered cell foci and focal inflammation were observed around bile ducts in the liver of all BPA-dosed groups in males, which achieved statistical significance from 0.5 mg/kg (ANOVA, Dunnett’s test, p<0.05). Toxicokinetic analysis revealed that systemic exposure to BPA was greater at early age (e.g., 210-fold in Cmax, and 26-fold in AUC at 50 mg/kg in male on day 1 over day 90) and in females (e.g., 4-fold in Cmax and 1.6-fold in AUC at 50 mg/kg vs. male on day 1), which might have stemmed from either age- or gender-dependent differences in metabolic capacity. These results may serve as evidence for the association between risk of cancer and exposure to low-dose BPA, especially in young children, as well as for varying toxicity of xenobiotics in different age and gender groups. © 2017 The Korean Society of Applied Pharmacology. | * |
dc.language | English | * |
dc.publisher | Korean Society of Applied Pharmacology | * |
dc.subject | Bile duct proliferation | * |
dc.subject | Bisphenol A | * |
dc.subject | Juvenile animals | * |
dc.subject | Toxicokinetics | * |
dc.title | Low-dose bisphenol A increases bile duct proliferation in juvenile rats: A possible evidence for risk of liver cancer in the exposed population? | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 25 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 545 | * |
dc.relation.lastpage | 552 | * |
dc.relation.journaltitle | Biomolecules and Therapeutics | * |
dc.identifier.doi | 10.4062/biomolther.2017.148 | * |
dc.identifier.wosid | WOS:000409152400011 | * |
dc.identifier.scopusid | 2-s2.0-85029152393 | * |
dc.author.google | Jeong J.S. | * |
dc.author.google | Nam K.T. | * |
dc.author.google | Lee B. | * |
dc.author.google | Pamungkas A.D. | * |
dc.author.google | Song D. | * |
dc.author.google | Kim M. | * |
dc.author.google | Yu W.-J. | * |
dc.author.google | Lee J. | * |
dc.author.google | Jee S. | * |
dc.author.google | Park Y.H. | * |
dc.author.google | Lim K.-M. | * |
dc.contributor.scopusid | 임경민(8916551700) | * |
dc.date.modifydate | 20240527131426 | * |