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New anticoagulants for the prevention and treatment of venous thromboembolism

Title
New anticoagulants for the prevention and treatment of venous thromboembolism
Authors
Kim J.H.Lim K.-M.Gwak H.S.
Ewha Authors
곽혜선임경민
SCOPUS Author ID
곽혜선scopus; 임경민scopus
Issue Date
2017
Journal Title
Biomolecules and Therapeutics
ISSN
1976-9148JCR Link
Citation
vol. 25, no. 5, pp. 461 - 470
Keywords
AnticoagulantHeparinVenous thromboembolismVitamin K antagonist
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Anticoagulant drugs, like vitamin K antagonists and heparin, have been the mainstay for the treatment and prevention of venous thromboembolic disease for many years. Although effective if appropriately used, traditional anticoagulants have several limitations such as unpredictable pharmacologic and pharmacokinetic responses and various adverse effects including serious bleeding complications. New oral anticoagulants have recently emerged as an alternative because of their rapid onset/offset of action, predictable linear dose-response relationships and fewer drug interactions. However, they are still associated with problems such as bleeding, lack of reversal agents and standard laboratory monitoring. In an attempt to overcome these drawbacks, key steps of the hemostatic pathway are investigated as targets for anticoagulation. Here we reviewed the traditional and new anticoagulants with respect to their targets in the coagulation cascade, along with their therapeutic advantages and disadvantages. In addition, investigational anticoagulant drugs currently in the development stages were introduced. © 2017 The Korean Society of Applied Pharmacology.
DOI
10.4062/biomolther.2016.271
Appears in Collections:
약학대학 > 약학과 > Journal papers
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