Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정병문 | * |
dc.date.accessioned | 2017-08-25T05:08:28Z | - |
dc.date.available | 2017-08-25T05:08:28Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 1525-7797 | * |
dc.identifier.issn | 1526-4602 | * |
dc.identifier.other | OAK-20983 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/235772 | - |
dc.description.abstract | Pluronics F127 (P, PEG-PPG-PEG triblock copolymer) was coupled with diphenylalanine (FF) to prepare FF-end-capped Pluronics (FFPFF). With increasing temperature from 10 to 60 degrees C, the FFPFF self-assembled to vesicles in water. The unimer-tovesicle transition accompanies endothermic enthalpy of 53.9 kcal/mol. Aqueous P and FFPFF solutions exhibited thermogelation in 15.0-24.0 wt %. The gel phase of FFPFF was stable up to 90 degrees C, whereas that of P turned into a sol again at 55-86 degrees C, indicating that end-capping with FF improved the gel stability against heat. In addition, the carboxylic acids of the FF end-groups can form coordination bonds with metal ions, and the gel modulus at 37 degrees C increased from 1521 KPa (P) to 20-25 KPa (FFPFF) to 24-28 KPa (FFPFF-Zn), and the duration of gel against water-erosion increased from 24 h (P) to 60 h (FFPFF-Zn), leading to a useful biomaterial for sustained drug delivery. The FFPFF-Zn gels implanted in the rats' subcutaneous layer induced a mild inflammatory responses. Contrary to the previous end-capping of Pluronics by poly(lactic acid), polycarprolactone, carboxylic acid, and so on that weakened the gel stability, the diphenylalanine end-capping strengthened the stability of Pluronics gel against heat and water erosion. This paper suggests that the control of polymer nanoassemblies directed by FF end-groups improves the mechanical properties and stability of the resulting thermogel and, thus, provides a useful drug delivery carrier with prolonged durability. | * |
dc.language | English | * |
dc.publisher | AMER CHEMICAL SOC | * |
dc.title | alpha,omega-Diphenylalanine-End-Capping of PEG-PPG-PEG Polymers Changes the Micelle Morphology and Enhances Stability of the Thermogel | * |
dc.type | Article | * |
dc.relation.issue | 7 | * |
dc.relation.volume | 18 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2214 | * |
dc.relation.lastpage | 2219 | * |
dc.relation.journaltitle | BIOMACROMOLECULES | * |
dc.identifier.doi | 10.1021/acs.biomac.7b00626 | * |
dc.identifier.wosid | WOS:000405444900020 | * |
dc.identifier.scopusid | 2-s2.0-85022323948 | * |
dc.author.google | Kim, Hae An | * |
dc.author.google | Lee, Hyun Jung | * |
dc.author.google | Hong, Ja Hye | * |
dc.author.google | Moon, Hyo Jung | * |
dc.author.google | Ko, Du Young | * |
dc.author.google | Jeong, Byeongmoon | * |
dc.contributor.scopusid | 정병문(7102237959) | * |
dc.date.modifydate | 20240118155902 | * |