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Serum persistent organic pollutants (POPs) and prostate cancer risk: A case-cohort study

Title
Serum persistent organic pollutants (POPs) and prostate cancer risk: A case-cohort study
Authors
Lim J.-E.Nam C.Yang J.Rha K.H.Lim K.-M.Jee S.H.
Ewha Authors
임경민임정은
SCOPUS Author ID
임경민scopus
Issue Date
2017
Journal Title
International Journal of Hygiene and Environmental Health
ISSN
1438-4639JCR Link
Citation
vol. 220, no. 5, pp. 849 - 856
Keywords
Cohort studiesEndocrine disruptorsPolychlorinated biphenylsProstatic neoplasms
Publisher
Elsevier GmbH
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
It is still unclear whether persistent organic pollutants (POPs) exposure increases the prostate cancer incidence risk. This prospective cohort study evaluated the associations between serum POPs concentrations and prostate cancer risk. Within a case-cohort study, we identified 110 people diagnosed with prostate cancer and randomly selected 256 sub-cohort participants without prostate cancer. Serum concentrations of 32 polychlorinated biphenyl (PCB) congeners and 19 organochlorine pesticides (OCPs) were measured. The hazard ratios (HRs) and 95% confidence interval (95% CI) for determining the associations between POPs and risk of prostate cancer were estimated using the weighted Cox regression model. Compared to the lowest tertile, increased risks of prostate cancer incidence were observed in the upper tertile of following PCBs: the moderately chlorinated (HR: 4.19; 95% CI: 1.30–13.54), the highly chlorinated (HR: 4.14; 95% CI: 1.75–9.79), biologically persistent as CYP1A and CYP2B inducers (HR: 4.44; 95% CI: 1.33–14.83), the sum of non- dioxin-like (HR: 3.47; 95% CI: 1.21–9.98), and ∑PCBs (HR: 4.29; 95% CI: 1.52–12.08). In dose-response curves, ∑PCBs was associated with the increased risk of prostate cancer. Our findings suggested a possible role of POPs in the etiology of prostate cancer. © 2017 Elsevier GmbH
DOI
10.1016/j.ijheh.2017.03.014
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약학대학 > 약학과 > Journal papers
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