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Hydrogel Based Biosensors for In Vitro Diagnostics of Biochemicals, Proteins, and Genes

Title
Hydrogel Based Biosensors for In Vitro Diagnostics of Biochemicals, Proteins, and Genes
Authors
Jung I.Y.Kim J.S.Choi B.R.Lee K.Lee H.
Ewha Authors
이혁진이규리
SCOPUS Author ID
이혁진scopus
Issue Date
2017
Journal Title
Advanced Healthcare Materials
ISSN
2192-2640JCR Link
Citation
vol. 6, no. 12
Keywords
biochemicalbiosensorsgeneshydrogelsproteins
Publisher
Wiley-VCH Verlag
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Hydrogel-based biosensors have drawn considerable attention due to their various advantages over conventional detection systems. Recent studies have shown that hydrogel biosensors can be excellent alternative systems to detect a wide range of biomolecules, including small biochemicals, pathogenic proteins, and disease specific genes. Due to the excellent physical properties of hydrogels such as the high water content and stimuli-responsive behavior of cross-linked network structures, this system can offer substantial improvement for the design of novel detection systems for various diagnostic applications. The other main advantage of hydrogels is the role of biomimetic three-dimensional (3D) matrix immobilizing enzymes and aptamers within the detection systems, which enhances their stability. This provides ideal reaction conditions for enzymes and aptamers to interact with substrates within the aqueous environment of the hydrogel. In this review, we have highlighted various novel detection approaches utilizing the outstanding properties of the hydrogel. This review summarizes the recent progress of hydrogel-based biosensors and discusses their future perspectives and clinical limitations to overcome. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
DOI
10.1002/adhm.201601475
Appears in Collections:
약학대학 > 약학과 > Journal papers
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