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Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp.

Title
Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp.
Authors
Le T.C.Yim C.-Y.Park S.Katila N.Yang I.Song M.C.Yoon Y.J.Choi D.-Y.Choi H.Nam S.-J.Fenical W.
Ewha Authors
윤여준송명종남상집
SCOPUS Author ID
윤여준scopus; 송명종scopus; 남상집scopus
Issue Date
2017
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 27, no. 14, pp. 3123 - 3126
Keywords
BACE1 inhibitorLodopyridoneMarine natural productsSaccharomonospora
Publisher
Elsevier Ltd
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
HPLC-UV guided isolation of the culture broth of a marine bacterium Saccharomonospora sp. CNQ-490 has led to the isolation of two new natural products, lodopyridones B and C (1 and 2) along with the previously reported lodopyridone A (3). Their chemical structures were established from the interpretation of 2D NMR spectroscopic data and the comparison of NMR data with the lodopyridone A (3). Lodopyridones B and C (1 and 2) possess the thiazole, and chloroquinoline groups which are characteristic features of these molecules. Lodopyridones A–C show weak inhibitory activities on the β-site amyloid precursor protein cleaving enzyme 1 (BACE1). © 2017 Elsevier Ltd
DOI
10.1016/j.bmcl.2017.05.035
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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