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Catechins activate muscle stem cells by Myf5 induction and stimulate muscle regeneration

Title
Catechins activate muscle stem cells by Myf5 induction and stimulate muscle regeneration
Authors
Kim A.R.Kim K.M.Byun M.R.Hwang J.-H.Park J.I.Oh H.T.Kim H.K.Jeong M.G.Hwang E.S.Hong J.-H.
Ewha Authors
황은숙
SCOPUS Author ID
황은숙scopus
Issue Date
2017
Journal Title
Biochemical and Biophysical Research Communications
ISSN
0006-291XJCR Link
Citation
vol. 489, no. 2, pp. 142 - 148
Keywords
CatechinsMuscle regenerationMyogenic differentiationPhosphoinositide 3-kinases/AktSatellite cells
Publisher
Elsevier B.V.
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Muscle weakness is one of the most common symptoms in aged individuals and increases risk of mortality. Thus, maintenance of muscle mass is important for inhibiting aging. In this study, we investigated the effect of catechins, polyphenol compounds in green tea, on muscle regeneration. We found that (−)-epicatechin gallate (ECG) and (−)-epigallocatechin-3-gallate (EGCG) activate satellite cells by induction of Myf5 transcription factors. For satellite cell activation, Akt kinase was significantly induced after ECG treatment and ECG-induced satellite cell activation was blocked in the presence of Akt inhibitor. ECG also promotes myogenic differentiation through the induction of myogenic markers, including Myogenin and Muscle creatine kinase (MCK), in satellite and C2C12 myoblast cells. Finally, EGCG administration to mice significantly increased muscle fiber size for regeneration. Taken together, the results suggest that catechins stimulate muscle stem cell activation and differentiation for muscle regeneration. © 2017 Elsevier Inc.
DOI
10.1016/j.bbrc.2017.05.114
Appears in Collections:
약학대학 > 약학과 > Journal papers
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