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Study on the mechanisms of seizure-like events suppression effect by electrical stimulation using a microelectrode array

Title
Study on the mechanisms of seizure-like events suppression effect by electrical stimulation using a microelectrode array
Authors
Ahn, SoraJo, SuminJun, Sang BeomLee, Hyang WoonLee, Seungjun
Ewha Authors
이승준이향운전상범
SCOPUS Author ID
이승준scopus; 이향운scopus; 전상범scopus
Issue Date
2017
Journal Title
NEUROREPORT
ISSN
0959-4965JCR Link1473-558XJCR Link
Citation
vol. 28, no. 9, pp. 471 - 478
Keywords
depolarization blockadeGranger causalityin-vitro experimentmicroelectrode arraypotassium accumulation hypothesisseizure-like eventtemporal lobe epilepsy
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
In this paper, we studied the mechanisms underlying the suppression of seizure-like events (SLEs) by electrical stimulation. We conducted an in-vitro experiment using entorhinal cortex combined hippocampal slices and two convulsant drugs, bicuculline and 4-aminopyridine, to induce spontaneous SLEs. We used a microelectrode array to observe network dynamics over the entire hippocampal area simultaneously, including regions far from the stimulation site. We stimulated the entorhinal cortex region, which has been determined to be a focus of SLEs by Granger causality analysis of multichannel time series data, by an external electrode. In bicuculline application, electrical stimulation showed a marked suppression effect, even though the sizes of the effective region differed. In 4-aminopyridine application, however, stimulation under the same conditions did not suppress the activities in similar to 80% of SLEs. The suppression effect was more remarkable in the areas surrounding the stimulation site in both cases. Our experimental results could support the neuronal depolarization blockade mechanism by accumulation of extracellular potassium ions, which is one of the most convincing mechanisms to understand seizure suppression phenomena because of electrical stimulation. Computer simulation using a neuronal network model also confirmed the mechanism. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
DOI
10.1097/WNR.0000000000000786
Appears in Collections:
엘텍공과대학 > 전자공학과 > Journal papers
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