View : 113 Download: 0
Study on the mechanisms of seizure-like events suppression effect by electrical stimulation using a microelectrode array
- Study on the mechanisms of seizure-like events suppression effect by electrical stimulation using a microelectrode array
- Ahn, Sora; Jo, Sumin; Jun, Sang Beom; Lee, Hyang Woon; Lee, Seungjun
- Ewha Authors
- 이승준; 이향운; 전상범
- SCOPUS Author ID
- 이승준; 이향운; 전상범
- Issue Date
- Journal Title
- 0959-4965; 1473-558X
- vol. 28, no. 9, pp. 471 - 478
- depolarization blockade; Granger causality; in-vitro experiment; microelectrode array; potassium accumulation hypothesis; seizure-like event; temporal lobe epilepsy
- LIPPINCOTT WILLIAMS & WILKINS
- SCI; SCIE; SCOPUS
- In this paper, we studied the mechanisms underlying the suppression of seizure-like events (SLEs) by electrical stimulation. We conducted an in-vitro experiment using entorhinal cortex combined hippocampal slices and two convulsant drugs, bicuculline and 4-aminopyridine, to induce spontaneous SLEs. We used a microelectrode array to observe network dynamics over the entire hippocampal area simultaneously, including regions far from the stimulation site. We stimulated the entorhinal cortex region, which has been determined to be a focus of SLEs by Granger causality analysis of multichannel time series data, by an external electrode. In bicuculline application, electrical stimulation showed a marked suppression effect, even though the sizes of the effective region differed. In 4-aminopyridine application, however, stimulation under the same conditions did not suppress the activities in similar to 80% of SLEs. The suppression effect was more remarkable in the areas surrounding the stimulation site in both cases. Our experimental results could support the neuronal depolarization blockade mechanism by accumulation of extracellular potassium ions, which is one of the most convincing mechanisms to understand seizure suppression phenomena because of electrical stimulation. Computer simulation using a neuronal network model also confirmed the mechanism. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
- Appears in Collections:
- 엘텍공과대학 > 전자공학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.