Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤여준 | - |
dc.date.accessioned | 2017-05-12T01:05:19Z | - |
dc.date.available | 2017-05-12T01:05:19Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 2156-8952 | - |
dc.identifier.issn | 2156-8944 | - |
dc.identifier.other | OAK-20536 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/235095 | - |
dc.description.abstract | Anthracyclines, such as doxorubicin, are effective anticancer drugs composed of a tetracyclic polyketide aglycone and one or more deoxysugar moieties, which play a critical role in their biological activity. A facile one-pot combinatorial biosynthetic system was developed for the generation of a range of glycosylated derivatives of anthracyclines. Cocultivation of Streptomyces venezuelae mutants producing two anthracycline aglycones with eight different nucleotide deoxysugar-producing S. venezuelae mutants that coexpress a substrate-flexible glycosyltransferase led to the generation of 16 aklavinone or e-rhodomycinone glycosides containing diverse deoxysugar moieties, seven of which are new. This demonstrates the potential of the one-pot combinatorial biosynthetic system based on cocultivation as a facile biological tool capable of combining diverse aglycones and deoxysugars to generate structurally diverse polyketides carrying engineered sugars for drug discovery and development. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | cocultivation | - |
dc.subject | Streptomyces | - |
dc.subject | glycosylation | - |
dc.subject | anthracycline | - |
dc.subject | deoxysugar | - |
dc.title | One-Pot Combinatorial Biosynthesis of Glycosylated Anthracyclines by Cocultivation of Streptomyces Strains Producing Aglycones and Nucleotide Deoxysugars | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 19 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 262 | - |
dc.relation.lastpage | 270 | - |
dc.relation.journaltitle | ACS COMBINATORIAL SCIENCE | - |
dc.identifier.doi | 10.1021/acscombsci.6600194 | - |
dc.identifier.wosid | WOS:000399061000007 | - |
dc.identifier.scopusid | 2-s2.0-85017524446 | - |
dc.author.google | Kim, Eunji | - |
dc.author.google | Song, Myoung Chong | - |
dc.author.google | Kim, Myoun Su | - |
dc.author.google | Beom, Ji Yoon | - |
dc.author.google | Jung, Jin A. | - |
dc.author.google | Cho, Hang Soo | - |
dc.author.google | Yoon, Yeo Joon | - |
dc.contributor.scopusid | 윤여준(7402126465) | - |
dc.date.modifydate | 20210915143054 | - |