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Photothermal activation of astrocyte cells using localized surface plasmon resonance of gold nanorods

Title
Photothermal activation of astrocyte cells using localized surface plasmon resonance of gold nanorods
Authors
Eom, KyungsikHwang, SeoyoungYun, SeunghyeonByun, Kyung MinJun, Sang BeomKim, Sung June
Ewha Authors
전상범
SCOPUS Author ID
전상범scopus
Issue Date
2017
Journal Title
JOURNAL OF BIOPHOTONICS
ISSN
1864-063XJCR Link1864-0648JCR Link
Citation
vol. 10, no. 4, pp. 486 - 493
Keywords
near-infrared laser stimulationlocalized surface plasmon resonancegold nanorodsastrocyte cellsintracellular calcium signaling
Publisher
WILEY-V C H VERLAG GMBH
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Although it has been revealed that astrocytes, generally known as star-shaped glial cells, play critical roles in the functions of central nervous system, there have been few efforts to directly modulate their activities and responses. In this study, an optical stimulation strategy for producing intracellular Ca2+ transients of astrocytes is demonstrated using near-infrared (NIR) light and localized surface plasmon resonance. It is presented that NIR stimulation of micro-second duration combined with gold nanorods (GNRs) efficiently produces stronger Ca2+ transients of astrocytes, which seems to be associated with a local heat generation by photothermal effects of GNRs. Since the proposed scheme can directly activate astrocytes with a high reliability, it is expected that GNR-mediated NIR stimulation could be utilized to facilitate minimally invasive physiological studies on the astrocyte functions.
DOI
10.1002/jbio.201600280
Appears in Collections:
엘텍공과대학 > 전자공학과 > Journal papers
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