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Photothermal activation of astrocyte cells using localized surface plasmon resonance of gold nanorods
- Photothermal activation of astrocyte cells using localized surface plasmon resonance of gold nanorods
- Eom, Kyungsik; Hwang, Seoyoung; Yun, Seunghyeon; Byun, Kyung Min; Jun, Sang Beom; Kim, Sung June
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- JOURNAL OF BIOPHOTONICS
- 1864-063X; 1864-0648
- vol. 10, no. 4, pp. 486 - 493
- near-infrared laser stimulation; localized surface plasmon resonance; gold nanorods; astrocyte cells; intracellular calcium signaling
- WILEY-V C H VERLAG GMBH
- SCIE; SCOPUS
- Although it has been revealed that astrocytes, generally known as star-shaped glial cells, play critical roles in the functions of central nervous system, there have been few efforts to directly modulate their activities and responses. In this study, an optical stimulation strategy for producing intracellular Ca2+ transients of astrocytes is demonstrated using near-infrared (NIR) light and localized surface plasmon resonance. It is presented that NIR stimulation of micro-second duration combined with gold nanorods (GNRs) efficiently produces stronger Ca2+ transients of astrocytes, which seems to be associated with a local heat generation by photothermal effects of GNRs. Since the proposed scheme can directly activate astrocytes with a high reliability, it is expected that GNR-mediated NIR stimulation could be utilized to facilitate minimally invasive physiological studies on the astrocyte functions.
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