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Tunneling Effect That Changes the Reaction Pathway from Epoxidation to Hydroxylation in the Oxidation of Cyclohexene by a Compound I Model of Cytochrome P450

Title
Tunneling Effect That Changes the Reaction Pathway from Epoxidation to Hydroxylation in the Oxidation of Cyclohexene by a Compound I Model of Cytochrome P450
Authors
Gupta, RanjanaLi, Xiao-XiCho, Kyung-BinGuo, MianLee, Yong-MinWang, YongFukuzumi, ShunichiNam, Wonwoo
Ewha Authors
남원우이용민Shunichi FukuzumiMian Guo
SCOPUS Author ID
남원우scopus; Shunichi Fukuzumiscopus; Mian Guoscopus
Issue Date
2017
Journal Title
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
ISSN
1948-7185JCR Link
Citation
vol. 8, no. 7, pp. 1557 - 1561
Publisher
AMER CHEMICAL SOC
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The rate constants of the C=C epoxidation and the C-H hydroxylation (i.e., allylic C-H bond activation) in the oxidation of cyclohexene by a high-valent iron(IV) oxo porphyrin pi-cation radical complex, [(TMP center dot+)Fe-IV(O)(Cl)] (1, TMP = meso-tetramesitylporphyrin dianion), were determined at various temperatures by analyzing the overall rate constants and the products obtained in the cyclohexene oxidation by 1, leading us to conclude that reaction pathway changes from the C=C epoxidation to C-H hydroxylation by decreasing reaction temperature. When cyclohexene was replaced by deuterated cyclohexene (cyclohexene-d(10)), the epoxidation pathway dominated irrespective of the reaction temperature. The temperature dependence of the rate constant of the C-H hydroxylation pathway in the reactions of cyclohexene and cyclohexene-d(10) by 1 suggests that there is a significant tunneling effect on the hydrogen atom abstraction of allylic C-H bonds of cyclohexene by 1, leading us to propose that the tunneling effect is a determining factor for the switchover of the reaction pathway from the C=C epoxidation pathway to the C-H hydroxylation pathway by decreasing reaction temperature. By performing density functional theory (DFT) calculations, the reaction energy barriers of the C=C epoxidation and C-H bond activation reactions by 1 were found to be similar, supporting the notion that small environmental changes, such as the reaction temperature, can flip the preference for one reaction to another.
DOI
10.1021/acs.jpclett.7b00461
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자연과학대학 > 화학·나노과학전공 > Journal papers
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