Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 장준 | * |
dc.date.accessioned | 2017-04-25T01:04:24Z | - |
dc.date.available | 2017-04-25T01:04:24Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 1932-6203 | * |
dc.identifier.other | OAK-20439 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/235001 | - |
dc.description.abstract | Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infection in infants, young children, and the elderly. Two subtypes of RSV, A and B, circulate alternately at 1-2-year intervals during epidemics. The attachment glycoprotein (G protein) of RSV is one of the major targets for immune responses. In this study, we generated a recombinant fusion protein, GcfAB, which consists of the central regions (a. a. residues 131-230) of the G proteins of both RSV A (A2 strain) and B (B1 strain) subtypes, and investigated immunogenicity, protective efficacy, and immunopathology. We immunized mice with GcfAB plus cholera toxin as a mucosal adjuvant via intranasal ( -IN) or sublingual (SL) routes. The IN group showed higher levels of RSV G-specific antibody responses, including serum IgG and mucosal IgA, compared with the SL group. On the contrary, more vigorous RSV G-specific CD4(+) T-cell responses were elicited in the SL group than in the IN group after RSV-A but not RSV-B viral challenge. Furthermore, the SL group showed more pulmonary eosinophil recruitment and body weight loss than did the IN group after RSV-A challenge. Both IN and SL immunization with GcfAB provided potential protection against both subtypes of infections. Together, these results suggest that vaccination with GcfAB via an IN route could be a universal vaccine regimen preventing both RSV A and B infections. | * |
dc.language | English | * |
dc.publisher | PUBLIC LIBRARY SCIENCE | * |
dc.title | Universal vaccine against respiratory syncytial virus A and B subtypes | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 12 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | PLOS ONE | * |
dc.identifier.doi | 10.1371/journal.pone.0175384 | * |
dc.identifier.wosid | WOS:000399371900166 | * |
dc.identifier.scopusid | 2-s2.0-85017107268 | * |
dc.author.google | Lee, Jeong-Yoon | * |
dc.author.google | Chang, Jun | * |
dc.contributor.scopusid | 장준(8735999100) | * |
dc.date.modifydate | 20231120165756 | * |