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자연과학대학
생명과학전공
Journal papers
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The role of macrophage lipophagy in reverse cholesterol transport
Title
The role of macrophage lipophagy in reverse cholesterol transport
Authors
Jeong S.-J.
;
Lee M.-N.
;
Oh G.T.
Ewha Authors
오구택
;
이미니
SCOPUS Author ID
오구택
; 이미니
Issue Date
2017
Journal Title
Endocrinology and Metabolism
ISSN
2093-596X
Citation
Endocrinology and Metabolism vol. 32, no. 1, pp. 41 - 46
Keywords
Atherosclerosis
;
Cholesterol efflux
;
Lipophagy
;
Macrophages
;
Reverse cholesterol transport
Publisher
Korean Endocrine Society
Indexed
SCOPUS; KCI
Document Type
Review
Abstract
Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis. Lipophagy has recently been identified as a new step in cholesterol ester hydrolysis that regulates cholesterol efflux, since it mobilizes cholesterol from lipid droplets of macrophages via autophagy and lysosomes. In this review, we briefly discuss recent advances regarding the mechanisms of the cholesterol efflux pathway in macrophage foam cells, and present lipophagy as a therapeutic target in the treatment of atherosclerosis. © 2017 Korean Endocrine Society.
DOI
10.3803/EnM.2017.32.1.41
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