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The role of macrophage lipophagy in reverse cholesterol transport

Title
The role of macrophage lipophagy in reverse cholesterol transport
Authors
Jeong S.-J.Lee M.-N.Oh G.T.
Ewha Authors
오구택이미니
SCOPUS Author ID
오구택scopus; 이미니scopusscopus
Issue Date
2017
Journal Title
Endocrinology and Metabolism
ISSN
2093-596XJCR Link
Citation
vol. 32, no. 1, pp. 41 - 46
Keywords
AtherosclerosisCholesterol effluxLipophagyMacrophagesReverse cholesterol transport
Publisher
Korean Endocrine Society
Indexed
SCOPUS; KCI scopus
Abstract
Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis. Lipophagy has recently been identified as a new step in cholesterol ester hydrolysis that regulates cholesterol efflux, since it mobilizes cholesterol from lipid droplets of macrophages via autophagy and lysosomes. In this review, we briefly discuss recent advances regarding the mechanisms of the cholesterol efflux pathway in macrophage foam cells, and present lipophagy as a therapeutic target in the treatment of atherosclerosis. © 2017 Korean Endocrine Society.
DOI
10.3803/EnM.2017.32.1.41
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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