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The serum level of 25-hydroxyvitamin D for maximal suppression of parathyroid hormone in children: The relationship between 25- hydroxyvitamin D and parathyroid hormone

Title
The serum level of 25-hydroxyvitamin D for maximal suppression of parathyroid hormone in children: The relationship between 25- hydroxyvitamin D and parathyroid hormone
Authors
Kang J.I.Lee Y.S.Han Y.J.Kong K.A.Kim H.S.
Ewha Authors
김혜순공경애
SCOPUS Author ID
김혜순scopus; 공경애scopus
Issue Date
2017
Journal Title
Korean Journal of Pediatrics
ISSN
1738-1061JCR Link
Citation
vol. 60, no. 2, pp. 45 - 49
Keywords
Parathyroid hormoneVitamin DVitamin D deficiency
Publisher
Korean Pediatric Society
Indexed
SCOPUS; KCI scopus
Abstract
Purpose: Serum level of 25-hydroxyvitamin D (25-OHD) is considered as the most appropriate marker of vitamin D status. However, only a few studies have investigated the relationship between 25-OHD and parathyroid hormone (PTH) in children. To this end, this study was aimed at evaluating the lowest 25- OHD level that suppresses the production of parathyroid hormone in children. Methods: A retrospective record review was performed for children aged 0.2 to 18 years (n=193; 106 boys and 87 girls) who underwent simultaneous measurements of serum 25-OHD and PTH levels between January 2010 and June 2014. Results: The inflection point of serum 25-OHD level for maximal suppression of PTH was at 18.0 ng/ mL (95% confidence interval, 14.3–21.7 ng/mL). The median PTH level of the children with 25-OHD levels of <18.0 ng/mL was higher than that of children with 25-OHD levels ≥ 18.0 ng/mL (P<0.0001). The median calcium level of children with 25-OHD levels<18.0 ng/mL was lower than that of children with 25-OHD levels≥18.0 ng/mL (P=0.0001). The frequency of hyperparathyroidism was higher in the children with 25-OHD levels<18.0 ng/mL than in the children with 25-OHD levels≥18.0 ng/mL (P<0.0001). Hypocalcemia was more prevalent in the children with 25-OHD levels<18.0 ng/mL than in the children with 25-OHD levels≥18.0 ng/mL (P<0.0001). Conclusion: These data suggest that a vitamin D level of 18.0 ng/mL could be the criterion for 25-OHD deficiency in children at the inflection point of the maximal suppression of PTH. © 2017 by The Korean Pediatric Society.
DOI
10.3345/kjp.2017.60.2.45
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의학전문대학원 > 의학과 > Journal papers
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