Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤주영 | * |
dc.contributor.author | Chen Xiaoqiang | * |
dc.date.accessioned | 2017-03-09T01:03:57Z | - |
dc.date.available | 2017-03-09T01:03:57Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 0956-5663 | * |
dc.identifier.other | OAK-20155 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/234716 | - |
dc.description.abstract | Synaptic Zn2+ plays an important role in neurotransmission and a neuromodulator. The development of the imaging tools for monitoring spatiotemporal changes taking place in synaptic Zn2+ concentrations is necessary in order to understand the role of Zn2+ in the function of many aspects of the glutamate system. In this work, two-photon probes 1 and 2, bearing ifenprodil-like tails that have affinity for NMDA receptors of neuronal cells, were designed and prepared. The two-photon fluorescent probe 1, which bears (N-(6-acetylnaphthalen-2-yl)-N-methylglycine) as two-photon fluorophore, enables high resolution imaging of neuronal cells. The two-photon fluorescent probe 2, which contains the di-2-picolylamine (DPA) as a Zn2+-binding site, the naphthalimide unit as the two-photon fluorophore, and the ifenprodil-like tail as the NMDA receptor binding moiety, can be employed for selective detection of Zn2+ located near the NMDA receptor and for monitoring concentration changes of Zn2+ in live neurons and hippocampal tissues. © 2017 Elsevier B.V. | * |
dc.language | English | * |
dc.publisher | Elsevier Ltd | * |
dc.subject | Fluorescent probes | * |
dc.subject | NMDA receptors | * |
dc.subject | Presynaptic terminal | * |
dc.subject | Two-photon imaging | * |
dc.subject | Zinc ions | * |
dc.title | Two-photon fluorescence sensors for imaging NMDA receptors and monitoring release of Zn2+ from the presynaptic terminal | * |
dc.type | Article | * |
dc.relation.volume | 91 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 770 | * |
dc.relation.lastpage | 779 | * |
dc.relation.journaltitle | Biosensors and Bioelectronics | * |
dc.identifier.doi | 10.1016/j.bios.2017.01.042 | * |
dc.identifier.wosid | WOS:000395599000107 | * |
dc.identifier.scopusid | 2-s2.0-85010840325 | * |
dc.author.google | Chen X. | * |
dc.author.google | Lim C.S. | * |
dc.author.google | Lee D. | * |
dc.author.google | Lee S. | * |
dc.author.google | Park S.J. | * |
dc.author.google | Kim H.M. | * |
dc.author.google | Yoon J. | * |
dc.contributor.scopusid | 윤주영(7403587371) | * |
dc.date.modifydate | 20240118162450 | * |