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Cyclocurcumin, an Antivasoconstrictive Constituent of Curcuma longa (Turmeric)
- Title
- Cyclocurcumin, an Antivasoconstrictive Constituent of Curcuma longa (Turmeric)
- Authors
- Kim, Keunyoung; Kim, Jung-Jun; Jung, Yeryeon; Noh, Ji-Yoon; Syed, Ahmed Shah; Kim, Chul Young; Lee, Moo-Yeol; Lim, Kyung-Min; Bae, Ok-Nam; Chung, Jin-Ho
- Ewha Authors
- 임경민
- SCOPUS Author ID
- 임경민
- Issue Date
- 2017
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- ISSN
- 0163-3864
1520-6025
- Citation
- JOURNAL OF NATURAL PRODUCTS vol. 80, no. 1, pp. 196 - 200
- Publisher
- AMER CHEMICAL SOC
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Despite the increasing attention on the therapeutic potential of Curcuma longa (turmeric), the biological activities of curcuminoids other than curcumin are not well understood. Here, we investigated antivasoconstrictive activities of C. longa extract and its ingredients using freshly isolated rat aortic rings. C. longa extract significantly suppressed agonist-stimulated vasoconstriction, and cyclocurcumin was found to be the most potent (IC50 against phenylephrine-induced vasoconstriction: 14.9 +/- 1.0 mu M) among the 10 tested ingredients including four curcuminoids. Cyclocurcumin significantly inhibited contraction of vascular smooth muscle, which was mediated by the suppression of myosin-light-chain phosphorylation and calcium influx via the L-type calcium channel. The inhibitory effect of cyclocurcumin was observed to be reversible and without cytotoxicity. Taken together, we demonstrated that cyclocurcumin, a bioactive ingredient in C. longa, may have a therapeutic potential as a novel antivasoconstrictive natural product.
- DOI
- 10.1021/acs.jnatprod.6b00331
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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