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Cyclocurcumin, an Antivasoconstrictive Constituent of Curcuma longa (Turmeric)

Title
Cyclocurcumin, an Antivasoconstrictive Constituent of Curcuma longa (Turmeric)
Authors
Kim, KeunyoungKim, Jung-JunJung, YeryeonNoh, Ji-YoonSyed, Ahmed ShahKim, Chul YoungLee, Moo-YeolLim, Kyung-MinBae, Ok-NamChung, Jin-Ho
Ewha Authors
임경민
SCOPUS Author ID
임경민scopus
Issue Date
2017
Journal Title
JOURNAL OF NATURAL PRODUCTS
ISSN
0163-3864JCR Link1520-6025JCR Link
Citation
vol. 80, no. 1, pp. 196 - 200
Publisher
AMER CHEMICAL SOC
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Despite the increasing attention on the therapeutic potential of Curcuma longa (turmeric), the biological activities of curcuminoids other than curcumin are not well understood. Here, we investigated antivasoconstrictive activities of C. longa extract and its ingredients using freshly isolated rat aortic rings. C. longa extract significantly suppressed agonist-stimulated vasoconstriction, and cyclocurcumin was found to be the most potent (IC50 against phenylephrine-induced vasoconstriction: 14.9 +/- 1.0 mu M) among the 10 tested ingredients including four curcuminoids. Cyclocurcumin significantly inhibited contraction of vascular smooth muscle, which was mediated by the suppression of myosin-light-chain phosphorylation and calcium influx via the L-type calcium channel. The inhibitory effect of cyclocurcumin was observed to be reversible and without cytotoxicity. Taken together, we demonstrated that cyclocurcumin, a bioactive ingredient in C. longa, may have a therapeutic potential as a novel antivasoconstrictive natural product.
DOI
10.1021/acs.jnatprod.6b00331
Appears in Collections:
약학대학 > 약학과 > Journal papers
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