Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박혜영 | * |
dc.contributor.author | 황은숙 | * |
dc.contributor.author | 정하나 | * |
dc.date.accessioned | 2017-03-01T01:03:02Z | - |
dc.date.available | 2017-03-01T01:03:02Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 2045-2322 | * |
dc.identifier.other | OAK-20191 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/234655 | - |
dc.description.abstract | Interferon-γ (IFN-γ), a critical inflammatory cytokine, is primarily produced by T helper 1 (Th1) cells and accelerates the pathogenesis of inflammatory colitis. Pharmacological suppression of IFN-γ production attenuates dysregulated inflammatory responses and may be beneficial for treating inflammatory disease. In this study, we aimed to discover potent anti-inflammatory compounds that suppress IFN-γ production and found that the novel benzoxazole derivatives, 2-((3,4-dichlorophenyl) amino) benzo[d]xazol-5-ol (DCPAB) and 2-((3,4-hydroxyphenyl) amino) benzo[d]xazol-5-ol (HPAB), suppressed IFN-γ production by T cells. Treatment of CD4+ T cells with DCPAB and HPAB selectively inhibited Th1 cell development, and DCPAB more potently suppressed IFN-γ than HPAB did. Interestingly, DCPAB and HPAB significantly suppressed the expression of T-box containing protein expressed in T cells (T-bet) that activates IFN-γ gene transcription. DCPAB additionally suppressed transcriptional activity of T-bet on IFN-γ gene promoter, whereas HPAB had no effect on T-bet activity. IFN-γ suppressive activity of DCPAB and HPAB was impaired in the absence of T-bet but was retrieved by the restoration of T-bet in T-bet-deficient T cells. Furthermore, DCPAB and HPAB attenuated inflammatory colitis development that was induced by CD4+ T cells in vivo. We suggest that the novel benzoxazole derivatives, DCPAB and HPAB, may have therapeutic effects on inflammatory colitis. © The Author(s) 2017. | * |
dc.language | English | * |
dc.publisher | Nature Publishing Group | * |
dc.title | Novel benzoxazole derivatives DCPAB and HPAB attenuate Th1 cell-mediated inflammation through T-bet suppression | * |
dc.type | Article | * |
dc.relation.volume | 7 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Scientific Reports | * |
dc.identifier.doi | 10.1038/srep42144 | * |
dc.identifier.wosid | WOS:000393463400001 | * |
dc.identifier.scopusid | 2-s2.0-85011838369 | * |
dc.author.google | Oh Y.J. | * |
dc.author.google | Kim D. | * |
dc.author.google | Oh S. | * |
dc.author.google | Jang E.J. | * |
dc.author.google | Won H.Y. | * |
dc.author.google | Jeong H. | * |
dc.author.google | Jeong M.G. | * |
dc.author.google | Choo H.-Y.P. | * |
dc.author.google | Hwang E.S. | * |
dc.contributor.scopusid | 박혜영(34972649500;57200273796) | * |
dc.contributor.scopusid | 황은숙(8688011100) | * |
dc.contributor.scopusid | 정하나(36673012100) | * |
dc.date.modifydate | 20240123102458 | * |