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FlexPro MD, a Mixture of Krill Oil, Astaxanthin, and Hyaluronic Acid, Suppresses Lipopolysaccharide-Induced Inflammatory Cytokine Production Through Inhibition of NF-kappa B

Title
FlexPro MD, a Mixture of Krill Oil, Astaxanthin, and Hyaluronic Acid, Suppresses Lipopolysaccharide-Induced Inflammatory Cytokine Production Through Inhibition of NF-kappa B
Authors
Park, Doo RiKo, RyeojinKwon, Suk HyungMin, BokkeeYun, Seong HoKim, Manh HeunMinatelli, JohnHill, StephenLee, Soo Young
Ewha Authors
이수영
SCOPUS Author ID
이수영scopus
Issue Date
2016
Journal Title
JOURNAL OF MEDICINAL FOOD
ISSN
1096-620XJCR Link1557-7600JCR Link
Citation
vol. 19, no. 12, pp. 1196 - 1203
Keywords
astaxanthincytokinesNF-kappa B
Publisher
MARY ANN LIEBERT, INC
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
FlexPro MD (R) (FP-MD), a novel multi-ingredient dietary supplement formulation, has been demonstrated to relieve knee joint pain in humans. However, the mechanisms of action responsible for the activity of FP-MD have not been elucidated. In this study, we show the anti-inflammatory effects of FP-MD in RAW264.7 macrophage cells and mice challenged with lipopolysaccharide (LPS). FP-MD significantly inhibited the mRNA levels of pro-inflammatory cytokines, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and IL-1 beta. In contrast, it elevated the mRNA levels of anti-inflammatory cytokine IL-10 in LPS-stimulated RAW264.7 cells. FP-MD markedly reduced LPS-induced phosphorylation levels of nuclear factor-kappa B (NF-kappa B) p65 and inhibitor of kappa B-alpha (I kappa B-alpha). Importantly, the anti-inflammatory effects of FP-MD were demonstrated in mice with LPS-induced inflammatory arthritis in which FP-MD significantly reduced the expression levels of pro-inflammatory cytokines and inflammatory markers. Thus, this study suggests that FP-MD has anti-inflammatory effects by inhibiting NF-kappa B that may offer a molecular basis for its pain relief property.
DOI
10.1089/jmf.2016.3787
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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