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Optimal radiation dose for patients with one to three lymph node positive breast cancer following breast-conserving surgery and anthracycline plus taxane-based chemotherapy: A retrospective multicenter analysis (KROG 1418)

Title
Optimal radiation dose for patients with one to three lymph node positive breast cancer following breast-conserving surgery and anthracycline plus taxane-based chemotherapy: A retrospective multicenter analysis (KROG 1418)
Authors
Kim, HaeyoungPark, WonYu, Jeong IlChoi, Doo HoHuh, Seung JaeKim, Yeon-JooLee, Eun SookLee, Keun SeokKang, Han-SungPark, In HaeShin, Kyung HwanKim, KyuboPark, Kyung RanKim, Yong BaeAhn, Sung JaLee, Jong HoonKim, Jin HeeChun, MisonLee, Hyung-SikKim, Jung SooLee, Jong-Young
Ewha Authors
김규보박경란
SCOPUS Author ID
김규보scopus; 박경란scopus
Issue Date
2017
Journal Title
ONCOTARGET
ISSN
1949-2553JCR Link
Citation
vol. 8, no. 1, pp. 1796 - 1804
Keywords
breast neoplasmsradiotherapydose-response relationshipprognosis
Publisher
IMPACT JOURNALS LLC
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background and Purpose: This study was performed to determine optimal radiation dose in pN1 breast cancer patients who received breast conserving surgery (BCS) and anthracycline plus taxane (AT)-based chemotherapy. Materials and Methods: Retrospective chart reviews were performed in 1,147 patients who were treated between January 2006 and December 2010. The impact of radiation dose on treatment outcomes was evaluated. Results: Median follow-up time was 66 months. The 5-year rate of disease-free survival (DFS) was 93.2%. Larger tumor size (> 20 mm), positive lymphovascular invasion, high histologic grade, and high ratio of positive nodes (> 0.1) were significantly associated with inferior DFS. By using the 4 factors related to DFS, patients were categorized into high-risk (with >= 3 factors) and low-risk (with < 3 factors) groups. In the high-risk group, higher radiation dose (> 60.3 Gy(EQD2)) was significantly associated with better DFS than the lower dose (<= 60.3 Gy(EQD2)). However, the radiation dose did not impact DFS in the low-risk group. Conclusions: Dosing of radiation affects the outcome of post-BCS radiotherapy in pN1 breast cancer. Doses of over 60.3 Gy(EQD2) were associated with better outcome in the high-risk patients.
DOI
10.18632/oncotarget.12882
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의학전문대학원 > 의학과 > Journal papers
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