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Recurrence outcomes after omission of postoperative radiotherapy following breast-conserving surgery for ductal carcinoma in situ of the breast: a multicenter, retrospective study in Korea (KROG 16-02)

Title
Recurrence outcomes after omission of postoperative radiotherapy following breast-conserving surgery for ductal carcinoma in situ of the breast: a multicenter, retrospective study in Korea (KROG 16-02)
Authors
Kim, KyuboJung, So-YounShin, Kyung HwanKim, Jin HoHan, WonshikLee, Han-ByoelHuh, Seung JaeChoi, Doo HoPark, WonAhn, Seung DoKim, Su SsanKim, Jin HeeSuh, Chang-OkKim, Yong BaeKim, In AhKim, SuzyKim, Yi-Jun
Ewha Authors
김규보
SCOPUS Author ID
김규보scopus
Issue Date
2017
Journal Title
BREAST CANCER RESEARCH AND TREATMENT
ISSN
0167-6806JCR Link1573-7217JCR Link
Citation
vol. 162, no. 1, pp. 77 - 83
Keywords
Ductal carcinoma in situRadiation therapyAgeResection margin
Publisher
SPRINGER
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
To evaluate the loco-regional recurrence (LRR) rate after breast-conserving surgery without postoperative radiotherapy (RT) for ductal carcinoma in situ (DCIS) of the breast. Between 2000 and 2010, 311 DCIS patients from 9 institutions were analyzed retrospectively. The median age was 47 (range, 20-82). The median tumor size was 7 mm (range, 0.01-76). Margin width was < 1 cm in 85 patients (27.3%), and nuclear grade was high in 37 patients (11.9%). Two hundred and three patients (65.3%) received tamoxifen. With a median follow-up of 74 months (range, 5-189), there were 11 local recurrences (invasive carcinoma in 6 and DCIS in 5) and 1 regional recurrence. The 7-year LRR rate was 3.8%. On univariate analysis, age and margin width were significant risk factors influencing LRR (p = 0.017 and 0.014, respectively). When age and margin width were combined among 211 patients whose margin width were available, the 7-year LRR rates were as follows (p < 0.001): (1) 0% in patients with age > 50 years and any margin width status (n = 64), (2) 1.2% in age <= 50 years and margin width >= 1 cm (n = 93), (3) 13.1% in age <= 50 years and margin width < 1 cm (n = 54). The LRR rate was very low in selected DCIS patients treated with breast-conserving surgery without postoperative RT. However, adjuvant RT should be considered for those with age <= 50 years and margin width < 1 cm.
DOI
10.1007/s10549-017-4111-1
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의과대학 > 의학과 > Journal papers
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