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Cadiolides J-M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja
- Title
- Cadiolides J-M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja
- Authors
- Wang, Weihong; Kim, Hiyoung; Patil, Rahul S.; Girl, Awadut G.; Won, Dong Hwan; Hahn, Dongyup; Sung, Youjung; Lee, Jusung; Choi, Hyukjae; Nam, Sang-Jip; Kang, Heonjoong
- Ewha Authors
- 남상집
- SCOPUS Author ID
- 남상집
- Issue Date
- 2017
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- ISSN
- 0960-894X
1464-3405
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS vol. 27, no. 3, pp. 574 - 577
- Keywords
- Tunicate; Pseudodistoma antinboja; Antibacterial activity
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Activity-guided fractionations of the tunicate Pseudodistoma antinboja yielded four new compounds of the cadiolide class (cadiolides J-M, 1, 3-5) along with a known one (cadiolide H, 2). The structures were defined by spectroscopic methods including X-ray crystallographic analysis. These compounds were evaluated for their antibacterial activity and exhibited potent antibacterial activity against all of the drug resistant strains tested with MICs comparable to those of marketed drugs such as vancomycin and linezolid. (C) 2016 Elsevier Ltd. All rights reserved.
- DOI
- 10.1016/j.bmcl.2016.12.016
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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