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Cadiolides J-M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja

Title
Cadiolides J-M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja
Authors
Wang, WeihongKim, HiyoungPatil, Rahul S.Girl, Awadut G.Won, Dong HwanHahn, DongyupSung, YoujungLee, JusungChoi, HyukjaeNam, Sang-JipKang, Heonjoong
Ewha Authors
남상집
SCOPUS Author ID
남상집scopus
Issue Date
2017
Journal Title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN
0960-894XJCR Link1464-3405JCR Link
Citation
vol. 27, no. 3, pp. 574 - 577
Keywords
TunicatePseudodistoma antinbojaAntibacterial activity
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Activity-guided fractionations of the tunicate Pseudodistoma antinboja yielded four new compounds of the cadiolide class (cadiolides J-M, 1, 3-5) along with a known one (cadiolide H, 2). The structures were defined by spectroscopic methods including X-ray crystallographic analysis. These compounds were evaluated for their antibacterial activity and exhibited potent antibacterial activity against all of the drug resistant strains tested with MICs comparable to those of marketed drugs such as vancomycin and linezolid. (C) 2016 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2016.12.016
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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