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Characteristics associated with progression in patients with of nontuberculous mycobacterial lung disease : a prospective cohort study
- Title
- Characteristics associated with progression in patients with of nontuberculous mycobacterial lung disease : a prospective cohort study
- Authors
- Kim, Soo Jung; Yoon, Soon Ho; Choi, Sun Mi; Lee, Jinwoo; Lee, Chang-Hoon; Han, Sung Koo; Yim, Jae-Joon
- Ewha Authors
- 김수정
- SCOPUS Author ID
- 김수정
- Issue Date
- 2017
- Journal Title
- BMC PULMONARY MEDICINE
- ISSN
- 1471-2466
- Citation
- BMC PULMONARY MEDICINE vol. 17
- Keywords
- Abdominal fat; Anthropometry; Body composition; Nontuberculous mycobacteria
- Publisher
- BIOMED CENTRAL LTD
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background: Patients with distinctive morphotype were more susceptible to nontuberculous mycobacterial lung disease (NTM-LD). However, little is known about the association between body morphotype and progression of NTM-LD. The aim of this study was to elucidate predictors of NTM-LD progression, focusing on body morphotype and composition. Methods: Data from patients with NTM-LD who participated in NTM cohort which started in 1 July 2011 were analyzed. Patients with more than 6 months of follow up were included for analysis. NTM-LD progression was defined as clinicianinitiated anti-NTM treatment, based on symptomatic and radiologic aggravation. Body morphotype and composition was measured at entry to the cohort using bioelectrical impedance analysis. Results: NTM-LD progressed in 47 out of 150 patients with more than 6 months of follow up. Patients with middle (adjusted hazard ratio [aHR], 2.758; 95% confidence interval [CI], 1.112-6.843) or lowest tertile (aHR, 3.084; 95% CI, 1.241-7. 668) of abdominal fat ratio had a higher risk of disease progression compared with the highest tertile. Other predictors for disease progression were presence of cavity on chest computed tomography (aHR, 4.577; 95% CI, 2.364-8.861), and serum albumin level < 3.5 g/dL (aHR, 12.943; 95% CI, 2.588-64.718). Conclusions: Progression of NTM-LD is associated with body composition. Lower abdominal fat ratio is an independent predictor of NTM-LD progression.
- DOI
- 10.1186/s12890-016-0349-3
- Appears in Collections:
- 의료원 > 의료원 > Journal papers
- Files in This Item:
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