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Characteristics associated with progression in patients with of nontuberculous mycobacterial lung disease : a prospective cohort study

Title
Characteristics associated with progression in patients with of nontuberculous mycobacterial lung disease : a prospective cohort study
Authors
Kim, Soo JungYoon, Soon HoChoi, Sun MiLee, JinwooLee, Chang-HoonHan, Sung KooYim, Jae-Joon
Ewha Authors
김수정
SCOPUS Author ID
김수정scopus
Issue Date
2017
Journal Title
BMC PULMONARY MEDICINE
ISSN
1471-2466JCR Link
Citation
vol. 17
Keywords
Abdominal fatAnthropometryBody compositionNontuberculous mycobacteria
Publisher
BIOMED CENTRAL LTD
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background: Patients with distinctive morphotype were more susceptible to nontuberculous mycobacterial lung disease (NTM-LD). However, little is known about the association between body morphotype and progression of NTM-LD. The aim of this study was to elucidate predictors of NTM-LD progression, focusing on body morphotype and composition. Methods: Data from patients with NTM-LD who participated in NTM cohort which started in 1 July 2011 were analyzed. Patients with more than 6 months of follow up were included for analysis. NTM-LD progression was defined as clinicianinitiated anti-NTM treatment, based on symptomatic and radiologic aggravation. Body morphotype and composition was measured at entry to the cohort using bioelectrical impedance analysis. Results: NTM-LD progressed in 47 out of 150 patients with more than 6 months of follow up. Patients with middle (adjusted hazard ratio [aHR], 2.758; 95% confidence interval [CI], 1.112-6.843) or lowest tertile (aHR, 3.084; 95% CI, 1.241-7. 668) of abdominal fat ratio had a higher risk of disease progression compared with the highest tertile. Other predictors for disease progression were presence of cavity on chest computed tomography (aHR, 4.577; 95% CI, 2.364-8.861), and serum albumin level < 3.5 g/dL (aHR, 12.943; 95% CI, 2.588-64.718). Conclusions: Progression of NTM-LD is associated with body composition. Lower abdominal fat ratio is an independent predictor of NTM-LD progression.
DOI
10.1186/s12890-016-0349-3
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의료원 > 의료원 > Journal papers
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