Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김원석 | * |
dc.date.accessioned | 2017-02-15T08:02:57Z | - |
dc.date.available | 2017-02-15T08:02:57Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 1615-4150 | * |
dc.identifier.issn | 1615-4169 | * |
dc.identifier.other | OAK-20049 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/234480 | - |
dc.description.abstract | Chemoselective Suzuki-Miyaura reactions on 3,5-and 4,6-dibromo-2-tosyloxypyridines have been studied for the preparation of trisubstituted pyridines. The optimized conditions allow for a facile access to 3,5-and 4,6-diaryl-2-tosyloxypyridines in yields of 8 to 99%. Further functionalization such as palladium-catalyzed amination and copper-free Sonogashira reaction of the tosylate group in the diarylpyridine derivatives obtained was accomplished for the synthesis of novel and biologically relevant tri-substituted pyridines. The formal synthesis of ficuseptine, a bioactive alkaloid, has also been achieved via the palladium-catalyzed cross-coupling reaction of 3,5-dibromo-2-tosyloxypyridine in 5 steps from 3,5-dibromo-2-hydroxypyridine with 50% overall yield. | * |
dc.language | English | * |
dc.publisher | WILEY-V C H VERLAG GMBH | * |
dc.subject | chemoselective Suzuki-Miyaura reaction | * |
dc.subject | copper-free Sonogashira reaction | * |
dc.subject | ficuseptine | * |
dc.subject | palladium-catalyzed amination | * |
dc.subject | trisubstituted pyridines | * |
dc.title | Synthesis of Trisubstituted Pyridines via Chemoselective Suzuki-Miyaura Coupling of 3,5-and 4,6-Dibromo-2-tosyloxypyridines | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 359 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 107 | * |
dc.relation.lastpage | 119 | * |
dc.relation.journaltitle | ADVANCED SYNTHESIS & CATALYSIS | * |
dc.identifier.doi | 10.1002/adsc.201600950 | * |
dc.identifier.wosid | WOS:000391812000001 | * |
dc.identifier.scopusid | 2-s2.0-85007586375 | * |
dc.author.google | Park, Cho-Hee | * |
dc.author.google | Kwon, Yong-Ju | * |
dc.author.google | Oh, In-Young | * |
dc.author.google | Kim, Won-Suk | * |
dc.contributor.scopusid | 김원석(57203484044) | * |
dc.date.modifydate | 20240220102223 | * |