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Assessment of musculoskeletal infection in rats to determine usefulness of SPIO-enhanced MRI

Title
Assessment of musculoskeletal infection in rats to determine usefulness of SPIO-enhanced MRI
Authors
Sang M.L.Lee S.H.Hae Y.K.Seung Y.B.Sung M.K.Myung J.S.
Ewha Authors
백승연
SCOPUS Author ID
백승연scopus
Issue Date
2007
Journal Title
American Journal of Roentgenology
ISSN
0361-803XJCR Link
Citation
vol. 189, no. 3, pp. 542 - 548
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
OBJECTIVE. The objective of our study was to evaluate the usefulness of superparamagnetic iron oxide (SPIO)-enhanced MRI in experimental models of infectious disease and to analyze the intracellular uptake of SPIO. MATERIALS AND METHODS. Nine rats with infectious arthritis of the knee or soft-tissue infection were imaged on an MRI unit on days 4-6 after IV injection of a bacterial suspension. All animals were imaged on a T2-weighted fast spin-echo sequence before and 24 hours after administration of SPIO. The nine rats were classified into two groups according to the dose of SPIO. We calculated the relative signal-to-noise ratio (SNR) change and compared the relative SNR change with the histologic findings. We analyzed iron-loaded cells and the intracellular uptake of iron particles according to the dose of SPIO. RESULTS. The SNR value decreased in proportion to the increase in the number of iron-laden macrophages or fibroblasts in the wall of the soft-tissue abscess (p < 0.01). The intracellular uptake of iron particles was shown in fibroblasts as well as in macrophages, and their uptake in the fibroblasts was greater than that in the macrophages (p < 0.05). There was no statistically significant difference in the intracellular uptake of iron particles according to the dose of SPIO (p > 0.1). CONCLUSION. SPIO-enhanced MRI can be useful in evaluating infectious disease of the joint or soft tissue and is influenced by the uptake of iron particles in fibroblasts as well as macrophages. © American Roentgen Ray Society.
DOI
10.2214/AJR.07.2213
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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