Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 백승연 | - |
dc.date.accessioned | 2017-02-15T08:02:40Z | - |
dc.date.available | 2017-02-15T08:02:40Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0361-803X | - |
dc.identifier.other | OAK-4235 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/234444 | - |
dc.description.abstract | OBJECTIVE. The objective of our study was to evaluate the usefulness of superparamagnetic iron oxide (SPIO)-enhanced MRI in experimental models of infectious disease and to analyze the intracellular uptake of SPIO. MATERIALS AND METHODS. Nine rats with infectious arthritis of the knee or soft-tissue infection were imaged on an MRI unit on days 4-6 after IV injection of a bacterial suspension. All animals were imaged on a T2-weighted fast spin-echo sequence before and 24 hours after administration of SPIO. The nine rats were classified into two groups according to the dose of SPIO. We calculated the relative signal-to-noise ratio (SNR) change and compared the relative SNR change with the histologic findings. We analyzed iron-loaded cells and the intracellular uptake of iron particles according to the dose of SPIO. RESULTS. The SNR value decreased in proportion to the increase in the number of iron-laden macrophages or fibroblasts in the wall of the soft-tissue abscess (p < 0.01). The intracellular uptake of iron particles was shown in fibroblasts as well as in macrophages, and their uptake in the fibroblasts was greater than that in the macrophages (p < 0.05). There was no statistically significant difference in the intracellular uptake of iron particles according to the dose of SPIO (p > 0.1). CONCLUSION. SPIO-enhanced MRI can be useful in evaluating infectious disease of the joint or soft tissue and is influenced by the uptake of iron particles in fibroblasts as well as macrophages. © American Roentgen Ray Society. | - |
dc.language | English | - |
dc.title | Assessment of musculoskeletal infection in rats to determine usefulness of SPIO-enhanced MRI | - |
dc.type | Article | - |
dc.relation.issue | 3 | - |
dc.relation.volume | 189 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 542 | - |
dc.relation.lastpage | 548 | - |
dc.relation.journaltitle | American Journal of Roentgenology | - |
dc.identifier.doi | 10.2214/AJR.07.2213 | - |
dc.identifier.wosid | WOS:000249038000011 | - |
dc.identifier.scopusid | 2-s2.0-34548225881 | - |
dc.author.google | Sang M.L. | - |
dc.author.google | Lee S.H. | - |
dc.author.google | Hae Y.K. | - |
dc.author.google | Seung Y.B. | - |
dc.author.google | Sung M.K. | - |
dc.author.google | Myung J.S. | - |
dc.contributor.scopusid | 백승연(7201371530) | - |
dc.date.modifydate | 20220901081003 | - |