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Design, synthesis, and preliminary biological evaluation of a novel triazole analogue of ceramide

Title
Design, synthesis, and preliminary biological evaluation of a novel triazole analogue of ceramide
Authors
Kim S.Cho M.Lee T.Lee S.Min H.-Y.Lee S.K.
Ewha Authors
이상국
Issue Date
2007
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 17, no. 16, pp. 4584 - 4587
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The amide bond of ceramide was replaced by the non-hydrolyzable 1,2,3-triazole functionality. Click chemistry was employed for synthesis of the designed analogues. Our preliminary biological evaluation indicated that the amide moiety of ceramide is amenable to bioisosteric substitution with the triazole moiety. Some of the analogues were more potent than C2-ceramide as cytotoxic agents, and the observed cytotoxicity was possibly mediated through the induction of apoptosis. © 2007 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2007.05.086
Appears in Collections:
약학대학 > 약학과 > Journal papers
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