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Thermosensitive micelles from PEGylated oligopeptides

Title
Thermosensitive micelles from PEGylated oligopeptides
Authors
Xu J.Z.Moon S.H.Jeong B.Sohn Y.S.
Ewha Authors
손연수정병문
SCOPUS Author ID
손연수scopus; 정병문scopus
Issue Date
2007
Journal Title
Polymer
ISSN
0032-3861JCR Link
Citation
vol. 48, no. 13, pp. 3673 - 3678
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
New thermosensitive and micelle-forming diblock copolymers were synthesized by amide coupling of carboxylated methoxy-poly(ethylene glycols) with hydrophobic oligopeptides and characterized by means of 1H NMR spectroscopy, elemental analysis, and dynamic light scattering (DLS) measurements. Stable micelles were formed from copolymers composed of MPEG550 or MPEG750 as a hydrophilic segment and the hexapeptide, GlyPheLeuGlyPheLeuEt, as a hydrophobic segment. All the present diblock copolymers exhibited thermosensitive properties by showing a lower critical solution temperature (LCST) in water. The LCST of the copolymers composed of relatively shorter MPEG350 and GlyPheLeuAspEt2 was observed at much higher temperature (48 °C) compared with the LCST (29 °C) of the cyclotriphosphazene analogues bearing the same hydrophilic and hydrophobic segments as side groups. The remarkably lower LCST of the cyclotriphosphazene analogue is presumed to be due to the structural effect of the cis-nongeminal conformation of its three hydrophobic oligopeptides, but such a structural effect was found to diminish as the chain lengths of the hydrophilic and hydrophobic blocks of the copolymers increased. © 2007 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.polymer.2007.04.061
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자연과학대학 > 화학·나노과학전공 > Journal papers
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