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Effects of dexamethasone on the expression of transforming growth factor-β in the mouse model of allergic rhinitis
- Effects of dexamethasone on the expression of transforming growth factor-β in the mouse model of allergic rhinitis
- Lee S.-S.; Won T.-B.; Kim J.-W.; Rhee C.-S.; Lee C.-H.; Hong S.-C.; Min Y.-G.
- Ewha Authors
- Issue Date
- Journal Title
- vol. 117, no. 8, pp. 1323 - 1328
- SCI; SCIE; SCOPUS
- OBJECTIVES/HYPOTHESIS: This study aimed to evaluate the effect of dexamethasone on the expression of transforming growth factor (TGF)-β in the mouse model of allergic rhinitis. STUDY DESIGN: Female BALB/c mice were randomly assigned to four groups, including two control groups and two treatment groups. METHODS: General sensitization and local challenge were performed with ovalbumin (OVA). In the treatment groups, dexamethasone was injected intraperitoneally 3 hours before general sensitization or local challenge. Symptom score, eosinophil infiltration, and immunostaining for TGF-β1 and CD4 in nasal mucosa, and TGF-β1 and OVA-specific immunoglobulin E (IgE) in sera were analyzed. RESULTS: Dexamethasone administration before general sensitization reduced the symptom score, OVA-specific IgE, and eosinophil infiltration and increased the serum level of TGF-β1 significantly. Dexamethasone administration before local challenge reduced only the eosinophil infiltration significantly. Immunoreactivity of TGF-β1 and CD4 was lower in both treatment groups. CONCLUSION: These results suggest that dexamethasone may play an important role in the regulation of allergic reactions by at least two mechanisms; one by suppressing allergic sensitization through decrease of CD4 T cells and increase of TGF-β, and the other by suppressing late allergic reactions through the inhibition of proliferation and chemotaxis of inflammatory cells such as eosinophils. © The American Laryngological, Rhinological & Otological Society, Inc.
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