Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이승신 | - |
dc.date.accessioned | 2017-02-15T08:02:35Z | - |
dc.date.available | 2017-02-15T08:02:35Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0023-852X | - |
dc.identifier.other | OAK-4173 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/234419 | - |
dc.description.abstract | OBJECTIVES/HYPOTHESIS: This study aimed to evaluate the effect of dexamethasone on the expression of transforming growth factor (TGF)-β in the mouse model of allergic rhinitis. STUDY DESIGN: Female BALB/c mice were randomly assigned to four groups, including two control groups and two treatment groups. METHODS: General sensitization and local challenge were performed with ovalbumin (OVA). In the treatment groups, dexamethasone was injected intraperitoneally 3 hours before general sensitization or local challenge. Symptom score, eosinophil infiltration, and immunostaining for TGF-β1 and CD4 in nasal mucosa, and TGF-β1 and OVA-specific immunoglobulin E (IgE) in sera were analyzed. RESULTS: Dexamethasone administration before general sensitization reduced the symptom score, OVA-specific IgE, and eosinophil infiltration and increased the serum level of TGF-β1 significantly. Dexamethasone administration before local challenge reduced only the eosinophil infiltration significantly. Immunoreactivity of TGF-β1 and CD4 was lower in both treatment groups. CONCLUSION: These results suggest that dexamethasone may play an important role in the regulation of allergic reactions by at least two mechanisms; one by suppressing allergic sensitization through decrease of CD4 T cells and increase of TGF-β, and the other by suppressing late allergic reactions through the inhibition of proliferation and chemotaxis of inflammatory cells such as eosinophils. © The American Laryngological, Rhinological & Otological Society, Inc. | - |
dc.language | English | - |
dc.title | Effects of dexamethasone on the expression of transforming growth factor-β in the mouse model of allergic rhinitis | - |
dc.type | Article | - |
dc.relation.issue | 8 | - |
dc.relation.volume | 117 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 1323 | - |
dc.relation.lastpage | 1328 | - |
dc.relation.journaltitle | Laryngoscope | - |
dc.identifier.doi | 10.1097/MLG.0b013e318064e84d | - |
dc.identifier.wosid | WOS:000248510800001 | - |
dc.identifier.scopusid | 2-s2.0-34548442461 | - |
dc.author.google | Lee S.-S. | - |
dc.author.google | Won T.-B. | - |
dc.author.google | Kim J.-W. | - |
dc.author.google | Rhee C.-S. | - |
dc.author.google | Lee C.-H. | - |
dc.author.google | Hong S.-C. | - |
dc.author.google | Min Y.-G. | - |
dc.contributor.scopusid | 이승신(8625984100) | - |
dc.date.modifydate | 20211210153418 | - |