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Radical approach to diabetic nephropathy

Title
Radical approach to diabetic nephropathy
Authors
Lee H.B.Seo J.Y.Yu M.R.Uh S.-T.Ha H.
Ewha Authors
하헌주
SCOPUS Author ID
하헌주scopus
Issue Date
2007
Journal Title
Kidney International
ISSN
0085-2538JCR Link
Citation
vol. 72, no. SUPPL. 106, pp. S67 - S70
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
There is increasing evidence that reactive oxygen species (ROS) play a major role in the development of diabetic complications. Oxidative stress is increased in diabetes and in chronic kidney disease (CKD). High glucose upregulates transforming growth factor-β1 (TGF-β1) and angiotensin II (Ang II) in renal cells and high glucose, TGF-β1, and Ang II all generate and signal through ROS. ROS mediate high glucose-induced activation of protein kinase C and nuclear factor-κB in renal cells. Intensive glycemic control and inhibition of Ang II delay the onset and progression of diabetic nephropathy, in part, through antioxidant activity. Conventional and catalytic antioxidants were shown to prevent or delay the onset of diabetic nephropathy. Transketolase activators and poly (ADP-ribose) polymerase inhibitors were shown to block major biochemical pathways of hyperglycemic damage. Combination of strategies to prevent overproduction of ROS, to increase the removal of preformed ROS, and to block ROS-induced activation of biochemical pathways leading to cellular damage may prove to the effective in preventing the development and progression of CKD in diabetes. © 2007 International Society of Nephrology.
DOI
10.1038/sj.ki.5002389
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약학대학 > 약학과 > Journal papers
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