Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김대기 | * |
dc.date.accessioned | 2017-02-15T08:02:25Z | - |
dc.date.available | 2017-02-15T08:02:25Z | - |
dc.date.issued | 2007 | * |
dc.identifier.issn | 0022-2623 | * |
dc.identifier.other | OAK-4078 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/234370 | - |
dc.description.abstract | A series of 4(5)-(6-alkylpyridin-2-yl)imidazoles 13a-p, 17a, and 17b have been synthesized and evaluated for ALK5 inhibitory activity in an enzyme assay and in cell-based luciferase reporter assays. The quinoxalinyl analogue 13e inhibited ALK5 phosphorylation with an IC 50 of 0.012 μM and showed more than 90% inhibition at 0.05 μM in a luciferase reporter assay using HaCaT cells transiently transfected with p3TP-luc reporter construct. The binding mode of 13e generated by flexible docking studies shows that 13e fits well into the active site cavity of ALK5 by forming several tight interactions. © 2007 American Chemical Society. | * |
dc.language | English | * |
dc.title | Synthesis and biological evaluation of 4(5)-(6-alkylpyridin-2-yl)imidazoles as transforming growth factor-β type 1 receptor kinase inhibitors | * |
dc.type | Article | * |
dc.relation.issue | 13 | * |
dc.relation.volume | 50 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 3143 | * |
dc.relation.lastpage | 3147 | * |
dc.relation.journaltitle | Journal of Medicinal Chemistry | * |
dc.identifier.doi | 10.1021/jm070129k | * |
dc.identifier.wosid | WOS:000247394600021 | * |
dc.identifier.scopusid | 2-s2.0-34347242484 | * |
dc.author.google | Kim D.-K. | * |
dc.author.google | Jang Y. | * |
dc.author.google | Ho S.L. | * |
dc.author.google | Park H.-J. | * |
dc.author.google | Yoo J. | * |
dc.contributor.scopusid | 김대기(35083694200) | * |
dc.date.modifydate | 20240118164500 | * |