NL repository
menu
검색
Library
Browse
Communities & Collections
By Date
Authors
Titles
Subject
My Repository
My Account
Receive email updates
Edit Profile
DSpace at EWHA
의과대학
의학과
Journal papers
View : 625 Download: 173
Synthesis of sulfonamides and evaluation of their histone deacetylase (HDAC) activity
Title
Synthesis of sulfonamides and evaluation of their histone deacetylase (HDAC) activity
Authors
Oh S.
;
Moon H.-I.
;
Son I.-H.
;
Jung J.-C.
Ewha Authors
오세관
;
정재철
SCOPUS Author ID
오세관
; 정재철
Issue Date
2007
Journal Title
Molecules
ISSN
1420-3049
Citation
Molecules vol. 12, no. 5, pp. 1125 - 1135
Indexed
SCIE; SCOPUS
Document Type
Article
Abstract
A simple synthesis of sulfonamides 4-22 as novel histone deacetylase (HDAC) inhibitors is described. The key synthetic strategies involve N-sulfonylation of L-proline benzyl ester hydrochloride (2) and coupling reaction of N-sulfonyl chloride 3 with amines in high yields. It was found that several compounds showed good cellular potency with the most potent compound 20 exhibiting an IC50 = 2.8 μM in vitro. © 2007 by MDPI.
DOI
10.3390/12051125
Appears in Collections:
의과대학
>
의학과
>
Journal papers
Files in This Item:
molecules-12-01125.pdf
(80.21 kB)
Download
Export
RIS (EndNote)
XLS (Excel)
XML
Show full item record
Find@EWHA
트윗하기
BROWSE
Communities & Collections
By Date
Authors
Titles
Subject