DSpace at EWHA: Synthesis of sulfonamides and evaluation of their histone deacetylase (HDAC) activity

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DC Field	Value	Language
dc.contributor.author	오세관	*
dc.contributor.author	정재철	*
dc.date.accessioned	2017-02-15T08:02:23Z	-
dc.date.available	2017-02-15T08:02:23Z	-
dc.date.issued	2007	*
dc.identifier.issn	1420-3049	*
dc.identifier.other	OAK-4063	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/234362	-
dc.description.abstract	A simple synthesis of sulfonamides 4-22 as novel histone deacetylase (HDAC) inhibitors is described. The key synthetic strategies involve N-sulfonylation of L-proline benzyl ester hydrochloride (2) and coupling reaction of N-sulfonyl chloride 3 with amines in high yields. It was found that several compounds showed good cellular potency with the most potent compound 20 exhibiting an IC50 = 2.8 μM in vitro. © 2007 by MDPI.	*
dc.language	English	*
dc.title	Synthesis of sulfonamides and evaluation of their histone deacetylase (HDAC) activity	*
dc.type	Article	*
dc.relation.issue	5	*
dc.relation.volume	12	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	1125	*
dc.relation.lastpage	1135	*
dc.relation.journaltitle	Molecules	*
dc.identifier.doi	10.3390/12051125	*
dc.identifier.wosid	WOS:000247200900018	*
dc.identifier.scopusid	2-s2.0-34249898119	*
dc.author.google	Oh S.	*
dc.author.google	Moon H.-I.	*
dc.author.google	Son I.-H.	*
dc.author.google	Jung J.-C.	*
dc.contributor.scopusid	오세관(7404103757)	*
dc.contributor.scopusid	정재철(7402897187)	*
dc.date.modifydate	20240123112233	*