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Synthesis of 1,3-diphenyl-2-propen-1-one derivatives and evaluation of their biological activities

Title
Synthesis of 1,3-diphenyl-2-propen-1-one derivatives and evaluation of their biological activities
Authors
Jang S.Jung J.-C.Oh S.
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2007
Journal Title
Bioorganic and Medicinal Chemistry
ISSN
0968-0896JCR Link
Citation
vol. 15, no. 12, pp. 4098 - 4105
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A simple synthesis and biological properties of 1,3-diphenyl-2-propen-1-ones 18-22 and 25-26 are described. The key synthetic strategies involve Grignard reaction of aldehyde 2 and oxidation reaction of 8-12 in high yields. The prepared compounds 18-22 and 25-26 were evaluated for free-radical scavenging, suppression of LPS-induced NO generation, and anti-excitotoxicity in vitro. It was found that a couple of compounds, especially 21 and 26, were potent suppressors of NO generation and demonstrated anti-excitotoxicity with the concentration range 10-20 μM in vitro. © 2007 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmc.2007.03.077
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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