Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오세관 | * |
dc.date.accessioned | 2017-02-15T08:02:20Z | - |
dc.date.available | 2017-02-15T08:02:20Z | - |
dc.date.issued | 2007 | * |
dc.identifier.issn | 0968-0896 | * |
dc.identifier.other | OAK-4030 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/234348 | - |
dc.description.abstract | A simple synthesis and biological properties of 1,3-diphenyl-2-propen-1-ones 18-22 and 25-26 are described. The key synthetic strategies involve Grignard reaction of aldehyde 2 and oxidation reaction of 8-12 in high yields. The prepared compounds 18-22 and 25-26 were evaluated for free-radical scavenging, suppression of LPS-induced NO generation, and anti-excitotoxicity in vitro. It was found that a couple of compounds, especially 21 and 26, were potent suppressors of NO generation and demonstrated anti-excitotoxicity with the concentration range 10-20 μM in vitro. © 2007 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.title | Synthesis of 1,3-diphenyl-2-propen-1-one derivatives and evaluation of their biological activities | * |
dc.type | Article | * |
dc.relation.issue | 12 | * |
dc.relation.volume | 15 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 4098 | * |
dc.relation.lastpage | 4105 | * |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry | * |
dc.identifier.doi | 10.1016/j.bmc.2007.03.077 | * |
dc.identifier.wosid | WOS:000246870400015 | * |
dc.identifier.scopusid | 2-s2.0-34247587038 | * |
dc.author.google | Jang S. | * |
dc.author.google | Jung J.-C. | * |
dc.author.google | Oh S. | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.date.modifydate | 20240118133340 | * |