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Production of aminoglycosides in non-aminoglycoside producing Streptomyces lividans TK24

Title
Production of aminoglycosides in non-aminoglycoside producing Streptomyces lividans TK24
Authors
Subba B.Kurumbang N.P.Jung Y.S.Yoon Y.J.Lee H.C.Liou K.Sohng J.K.
Ewha Authors
윤여준
SCOPUS Author ID
윤여준scopus
Issue Date
2007
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 17, no. 7, pp. 1892 - 1896
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The pRBM4 cosmid, which harbors a putative cluster of genes spanning a 31.8-kb chromosomal region of the ribostamycin producer Streptomyces ribosidificus ATCC 21294, was heterologously expressed in Streptomyces lividans TK24. ESI-MS/MS, HPLC, and LC-ESI MS analyses showed that the transformation gave rise to ribostamycin production in various culture broths. This is the first report of heterologous aminoglycoside production. © 2007 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2007.01.035
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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