Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김원기 | - |
dc.date.accessioned | 2017-02-15T08:02:09Z | - |
dc.date.available | 2017-02-15T08:02:09Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1071-5762 | - |
dc.identifier.other | OAK-3917 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/234293 | - |
dc.description.abstract | Nuclear factor-kappaB (NF-κB) has a dual role in the promotion or attenuation of cell death. Here, we demonstrated the role of NF-κB in the H2O2-induced death of astrocytes. H2O2 evoked the release of lactate dehydrogenase (LDH), a marker of cell death, and concomitantly decreased the DNA binding and transcriptional activity of NF-κ3ba;B in cultured astrocytes. H2O2-induced astrocyte death was markedly increased by the co-treatment with pyrrolidinedithiocarbamate, an NF-κB inhibitor. Moreover, the elevation of constitutive NF-κB activity by overexpressing p65 NF-κB subunit attenuated H2O2 toxicity, whereas NF-κB inhibition by overexpressing Iκba;B potentiated the toxicity. NF-κB activity and H2O2 cytotoxicity was further found to be dependent on cell density. Compared with astrocytes in low cell density, those in high cell density exhibited a higher constitutive NF-κB activity and a stronger resistance to H2O2 cytotoxicity. These results indicate that the constitutive activity of NF-κB in astrocytes is required for their survival under oxidative stress such as H2O2. | - |
dc.language | English | - |
dc.title | Hydrogen peroxide induces the death astrocytes through the down-regulation of the constitutive nuclear factor-kappaB activity | - |
dc.type | Article | - |
dc.relation.issue | 5 | - |
dc.relation.volume | 41 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 555 | - |
dc.relation.lastpage | 562 | - |
dc.relation.journaltitle | Free Radical Research | - |
dc.identifier.doi | 10.1080/10715760601173010 | - |
dc.identifier.wosid | WOS:000245589100006 | - |
dc.identifier.scopusid | 2-s2.0-34047180590 | - |
dc.author.google | Choi J.-J. | - |
dc.author.google | Choi J. | - |
dc.author.google | Kang C.-D. | - |
dc.author.google | Chen X. | - |
dc.author.google | Wu C.-F. | - |
dc.author.google | Ko K.H. | - |
dc.author.google | Kim W.-K. | - |
dc.contributor.scopusid | 김원기(34770946200) | - |
dc.date.modifydate | 20211210152058 | - |