Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영주 | * |
dc.date.accessioned | 2017-02-15T08:02:04Z | - |
dc.date.available | 2017-02-15T08:02:04Z | - |
dc.date.issued | 2007 | * |
dc.identifier.issn | 0960-894X | * |
dc.identifier.other | OAK-3877 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/234272 | - |
dc.description.abstract | In this report, we prepared some 3-(2′,3′-epoxypropoxy)xanthones and their epoxide ring opened halohydrin analogues, and evaluated their cytotoxicity and topoisomerase II inhibition activity using doxorubicin and etoposide as references, respectively. Another xanthone compound 9, 1,3-di(2′,3′-epoxypropoxy)xanthone, was also synthesized and its DNA cross-linking property including other two biological activities investigated. The biological test results showed compound 9 possessed excellent cytotoxic and topoisomerase II inhibitory activity than other compounds tested. It also exhibited significant DNA cross-linking activities. © 2006 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.title | Synthesis of new xanthone analogues and their biological activity test-Cytotoxicity, topoisomerase II inhibition, and DNA cross-linking study | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 17 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1163 | * |
dc.relation.lastpage | 1166 | * |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry Letters | * |
dc.identifier.doi | 10.1016/j.bmcl.2006.12.030 | * |
dc.identifier.wosid | WOS:000244943300004 | * |
dc.identifier.scopusid | 2-s2.0-33846898056 | * |
dc.author.google | Woo S. | * |
dc.author.google | Jung J. | * |
dc.author.google | Lee C. | * |
dc.author.google | Kwon Y. | * |
dc.author.google | Na Y. | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.date.modifydate | 20240422124907 | * |