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Development of new microencapsulation techniques useful for the preparation of PLGA microspheres

Title
Development of new microencapsulation techniques useful for the preparation of PLGA microspheres
Authors
Sah H.Lee B.-J.
Ewha Authors
사홍기
SCOPUS Author ID
사홍기scopus
Issue Date
2006
Journal Title
Macromolecular Rapid Communications
ISSN
1022-1336JCR Link
Citation
vol. 27, no. 21, pp. 1845 - 1851
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Intensive efforts were made to develop an efficient, novel microencapsulation system useful to encapsulate a model drug, risperidone, to PLGA microspheres. Methyl dichloroacetate was used as a dispersed solvent for the first time, since it possessed excellent solvency power on PLGA and readily underwent ammonolysis. A dispersed phase composed of methyl dichloroacetate, risperidone, and PLGA was emulsified in an aqueous phase to form an O/W emulsion. Adding ammonia solution into the emulsion rapidly converted methyl dichloroacetate into water-soluble dichloroacetamide and methanol. As a result, emulsion droplets were immediately transformed into hardened microspheres. The new microencapsulation system allowed us to make PLGA microspheres with a drug payload of > 40 wt.-% and attain almost complete encapsulation efficiencies. In summary, preparing an O/W emulsion and subjecting the emulsion to ammonolysis led to development of an efficient, novel microencapsulation system. It was anticipated that the new system could make it possible to load other bioactive materials into microspheres made of various types of hydrophobic polymers. © 2006 WILEY-VCH Verlag GmbH & Co. KGaA.
DOI
10.1002/marc.200600531
Appears in Collections:
약학대학 > 약학과 > Journal papers
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