Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수영 | * |
dc.date.accessioned | 2017-02-15T08:02:37Z | - |
dc.date.available | 2017-02-15T08:02:37Z | - |
dc.date.issued | 2006 | * |
dc.identifier.issn | 0014-5793 | * |
dc.identifier.other | OAK-3621 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/234139 | - |
dc.description.abstract | In order to demonstrate that cellular redox status undergoes decreased reduction during osteoclast differentiation and further decreased reduction during osteoclastic bone resorption, we analyzed γ-glutamylcysteinyl synthetase activity, a glutathione synthesis rate-limiting enzyme, and total glutathione and thiol groups. Moderate and severe redox shifts towards a more oxidizing environment induced gradual increases and decreases in osteoclastogenesis. Moreover, while severe glutathione depletion inhibited bone resorption, moderate glutathione repletion enhanced bone resorption. In summary, our observations suggest that there is a threshold for redox status, representing biphasic patterns in osteoclast differentiation and function. © 2006 Federation of European Biochemical Societies. | * |
dc.language | English | * |
dc.title | Bimodal actions of reactive oxygen species in the differentiation and bone-resorbing functions of osteoclasts | * |
dc.type | Article | * |
dc.relation.issue | 24 | * |
dc.relation.volume | 580 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 5661 | * |
dc.relation.lastpage | 5665 | * |
dc.relation.journaltitle | FEBS Letters | * |
dc.identifier.doi | 10.1016/j.febslet.2006.09.015 | * |
dc.identifier.wosid | WOS:000241461000009 | * |
dc.identifier.scopusid | 2-s2.0-33749534719 | * |
dc.author.google | Kim H. | * |
dc.author.google | Kim I.Y. | * |
dc.author.google | Lee S.Y. | * |
dc.author.google | Jeong D. | * |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | * |
dc.date.modifydate | 20240415140424 | * |