Stereoselective synthesis of 2′-C-methyl-cyclopropyl-fused carbanucleosides as potential anti-HCV agents

Abstract

(Chemical Equation Presented) Stereoselective synthesis of 2′-C-methyl-cyclopropyl-fused carbanucleosides was accomplished via stereoselective cyclopropanation, regioselective cleavage of the isopropylidene group, stereoselective Grignard reaction, and cyclic sulfate chemistry. © 2006 American Chemical Society.