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Surface-imprinted, thermosensitive, core-shell nanosphere for molecular recognition

Title
Surface-imprinted, thermosensitive, core-shell nanosphere for molecular recognition
Authors
Ko D.Y.Lee H.J.Jeong B.
Ewha Authors
이화정정병문
SCOPUS Author ID
이화정scopus; 정병문scopus
Issue Date
2006
Journal Title
Macromolecular Rapid Communications
ISSN
1022-1336JCR Link
Citation
vol. 27, no. 16, pp. 1367 - 1372
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The D-glucose imprinted core-shell nanosphere with an average size of ≈60 to 80 nm showed a significant preference for the binding of D-glucose than the non-imprinted core-shell nanosphere. Depending on temperature, the binding site in the shell with N-isopropylacrylamide oligomer underwent a significant change in binding affinity. In addition, the D-glucose imprinted core-shell nanosphere showed a two times higher affinity for D-glucose than L-glucose, suggesting chiral recognition of the binding site. The core-shell nanosphere reported here is a good biomimetic model system with a well-defined morphology, high surface area, and variable binding affinity through a change in temperature. © 2006 WILEY-VCH Verlag GmbH & Co. KGaA.
DOI
10.1002/marc.200600259
Appears in Collections:
약학대학 > 약학과 > Journal papers
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