View : 61 Download: 0

S-Allyl-l-cysteine attenuates cerebral ischemic injury by scavenging peroxynitrite and inhibiting the activity of extracellular signal-regulated kinase

Title
S-Allyl-l-cysteine attenuates cerebral ischemic injury by scavenging peroxynitrite and inhibiting the activity of extracellular signal-regulated kinase
Authors
Kim J.-M.Lee J.-C.Chang N.Chun H.S.Kim W.-K.
Ewha Authors
김원기장남수
SCOPUS Author ID
장남수scopus
Issue Date
2006
Journal Title
Free Radical Research
ISSN
1071-5762JCR Link
Citation
vol. 40, no. 8, pp. 827 - 835
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
S-Allyl-l-cysteine (SAC) has been shown to reduce ischemic injury due to its antioxidant activity. However, the antioxidant property of SAC has been controversial. The present study investigated the neuroprotective mechanism of SAC in cerebral ischemic insults. SAC decreased the size of infarction after transient or global ischemic insults. While it did not alter the N-methyl-d-aspartate excitotoxicity, SAC significantly scavenged the endogenously or exogenously produced ONOO - and reduced ONOO - cytotoxicity. In contrast, SAC has much lower scavenging activity against H 2O 2, or NO. Further, SAC inhibited the activity of extracellular signal-regulated kinase (ERK) increased in cultured neurons exposed to oxygen-glucose deprivation or in rat brain tissue after transient middle cerebral artery occlusion. The neuroprotective effect of SAC was mimicked by the ERK inhibitor U0125. The present results indicate that SAC exert its neuroprotective effect by scavenging ONOO - and inhibiting the ERK signaling pathway activated during initial hypoxic/ischemic insults.
DOI
10.1080/10715760600719540
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE