A chiral ketone for enantioselective recognition of 1,2-amino alcohols

Abstract

A novel auxillary chiral ketone has been designed, synthesized, and used to enantioselectively recognize 1,2-amino alcohols. This work proves that the keto group can serve as a chiral recognition center by imine formation supported by resonance assisted hydrogen bonding (RAHB). © 2007 Elsevier Ltd. All rights reserved.