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Anticancer drug-inorganic nanohybrid and its cellular interaction

Title
Anticancer drug-inorganic nanohybrid and its cellular interaction
Authors
Kim J.Y.Choi S.-J.Oh J.-M.Park T.Choy J.-H.
Ewha Authors
최진호
SCOPUS Author ID
최진호scopus
Issue Date
2007
Journal Title
Journal of Nanoscience and Nanotechnology
ISSN
1533-4880JCR Link
Citation
vol. 7, no. 11, pp. 3700 - 3705
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
An anticancer drug, methotrexate (MTX), has been successfully hybridized with layered double hydroxide (LDH) through co-precipitation route to produce MTX-LDH nanohybrids (MTX-LDH). According to the X-ray diffraction and FT-IR spectroscopy, it was confirmed that MTX molecules are stabilized in the interlayer space of LDHs by electrostatic interaction, maintaining their functional groups and structural integrity. According to the drug release study, the total amount of released MTX from the LDH lattice was determined to be larger under a simulated intracellular lysosomal condition (pH = 4.5) than simulated body fluid one (pH = 7.4). It is, therefore, expected that the MTX molecules in MTX-LDH can be effectively released in lysosomes, since the MTX release could be accelerated via ion-exchange reaction and dissolution of LDH in an acidic lysosomal condition. We also examined the anticancer efficacy of MTX-LDH in human breast adenocarcinoma MCF-7 cells. The cellular uptake of MTX was considerably higher in MTX-LDH-treated cells than in free MTX-treated cells, giving a lower IC 50 value for the former than the latter. All the results demonstrated that the MTX-LDH nanohybrid allows the efficient drug delivery in cells, and thus enhances drug efficacy. Copyright © 2007 American Scientific Publishers All rights reserved.
DOI
10.1166/jnn.2007.061
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자연과학대학 > 화학·나노과학전공 > Journal papers
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