Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장준 | * |
dc.date.accessioned | 2017-01-18T02:01:30Z | - |
dc.date.available | 2017-01-18T02:01:30Z | - |
dc.date.issued | 2007 | * |
dc.identifier.issn | 0953-8178 | * |
dc.identifier.other | OAK-4383 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233965 | - |
dc.description.abstract | In addition to TCR and co-stimulatory signals, inflammatory cytokines such as IL-12 provide important signals for differentiation and survival of activated CD8 T cells. In the present study, to investigate the mechanisms by which IL-12 priming contributes to activation and enhanced survival of CD8 T cells, we searched the differentially regulated genes and markers by IL-12 during antigenic stimulation. Here, we show that IL-12 priming results in the increased subpopulation of CD127hi cells, which differentiates into long-lived memory cells. We also found that IL-12 priming induces IL-10 expression from activated CD8 T cells, which is distinct from CD127 up-regulation. Direct IL-10 priming of CD8 T cells results in the significant increase of effector and memory CD8 T cell population after adoptive transfer, and this priming effect is closely associated with less susceptibility to apoptosis. Although IL-10 is known as a cytokine with anti-inflammatory and immunosuppressive properties, our results have shown that IL-10 has a direct and positive effect on the survival of CD8 T cells. Together, we suggest that IL-10-dependent and independent effects of IL-12 play important roles in regulating differentiation and survival of activated CD8 T cells into effector and memory cells. © The Author 2007. Published by Oxford University Press on behalf of The Japanese Society for Immunology. All rights reserved. | * |
dc.language | English | * |
dc.title | Phenotypic changes induced by IL-12 priming regulate effector and memory CD8 T cell differentiation | * |
dc.type | Article | * |
dc.relation.issue | 9 | * |
dc.relation.volume | 19 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1039 | * |
dc.relation.lastpage | 1048 | * |
dc.relation.journaltitle | International Immunology | * |
dc.identifier.doi | 10.1093/intimm/dxm072 | * |
dc.identifier.wosid | WOS:000250681600002 | * |
dc.identifier.scopusid | 2-s2.0-34548704807 | * |
dc.author.google | Lee J.-B. | * |
dc.author.google | Lee K.-A. | * |
dc.author.google | Chang J. | * |
dc.contributor.scopusid | 장준(8735999100) | * |
dc.date.modifydate | 20231120165756 | * |