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Effect of acidic degradation products of poly(lactic-co-glycolic)acid on the apatite-forming ability of poly(lactic-co-glycolic)acid-siloxane nanohybrid material

Title
Effect of acidic degradation products of poly(lactic-co-glycolic)acid on the apatite-forming ability of poly(lactic-co-glycolic)acid-siloxane nanohybrid material
Authors
Rhee S.-H.Seung J.L.
Ewha Authors
이승진
SCOPUS Author ID
이승진scopus
Issue Date
2007
Journal Title
Journal of Biomedical Materials Research - Part A
ISSN
1549-3296JCR Link
Citation
vol. 83, no. 3, pp. 799 - 805
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The effect of poly(lactic-co-glycolic) acid (PLGA) degradation products on the apatite-forming ability of a PLGA-siloxane nanohybrid material were investigated. Two PLGA copolymer compositions with low and high degradability were used in the experiment. The PLGA-siloxane nanohybrid materials were synthesized by end-capping PLGA with acid end-groups using 3-isocyanatopropyl triethoxysilane following the sol-gel reaction with calcium nitrate tetrahydrate. Two nanohybrid materials that had different degradability were exposed to simulated body fluid (SBF) for 1-28 days at 36.5°C. The low degradable PLGA hybrid showed apatite-forming ability within 3 days of incubation while the high degradable one did not within 28 days testing period. The results were explained in terms of the acidity of the PLGA degradation products, which could directly influence on the apatite dissolution. © 2007 Wiley Periodicals, Inc.
DOI
10.1002/jbm.a.31405
Appears in Collections:
약학대학 > 약학과 > Journal papers
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